TsCl promoted deoxygenative phosphorothiolation of quinoline <i>N</i>-oxides towards <i>S</i>-quinolyl phosphorothioates
Li-Yao Wu, Tian Huang, Zhong-Ying Tian, Xiang-Qin Xu, Sha Peng, Long‐Yong Xie
Abstract
-dialkylphosphorothioates was developed. The reaction performed well under transition-metal-free conditions at room temperature with a very short reaction time (10-20 min). Preliminary studies showed that the current transformation underwent a nucleophilic substitution process.
Topics & Concepts
QuinolineChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistrySulfur-Based Synthesis TechniquesSynthesis and Reactivity of Sulfur-Containing CompoundsSynthesis of heterocyclic compounds