The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
Ling Ran, Zhengliang Yue, Mengqu Ran, Qiao Liu, Xingxing Su, Lisha Wang, Shuqiong Wen, Luming Xu, Shun� Lei, Zhanpeng Ou, Jianjun Hu, Yan Zhang, Chenxi Qin, Yuzhu Wang, Qinyi He, Yezi Chen, Wen Liu, Lilin Ye, Qizhao Huang, Qizhao Huang, Lifan Xu, Lifan Xu
Abstract
During tumorigenesis, the recently identified tumor-specific memory T cells in draining lymph nodes (TdLN-T TSM cells) play a pivotal role in tumor repression that gives rise to progenitor exhausted T (T PEX ) cells and further replenishes tumor-specific CD8 + T cells residing in the tumor microenvironment (TME). However, how T TSM cells are maintained in TdLN is largely unknown. Here, we show that the transcription regulator ID3 (inhibitor of DNA binding 3) is highly expressed by T TSM cells compared with other CD8 + T cell subsets. The deficiency of ID3 significantly interrupts the maintenance of T TSM and T PEX cells, resulting in decreased tumor-infiltrating CD8 + T cells and impaired tumor control. Consistent with this, overexpression of ID3 in CD8 + T cells increases the T TSM cell population and enhances the anti-tumor immune response.