Chalcone Derivatives with a High Potential as Multifunctional Antioxidant Neuroprotectors
Adriana Pérez‐González, Romina Castañeda‐Arriaga, Eduardo Gabriel Guzmán‐López, Luis Felipe Hernández‐Ayala, Annia Galano
Abstract
-methyltransferase (COMT), acetylcholinesterase (AChE), and monoamine oxidase B (MAO-B) inhibitors. Therefore, these four molecules are proposed as promising candidates to act as multifunctional antioxidants with neuroprotective effects.
Topics & Concepts
ChalconeChemistryMonoamine oxidaseStereochemistryAcetylcholinesteraseAscorbic acidCombinatorial chemistryBiochemistryEnzymeFood scienceFree Radicals and AntioxidantsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods