Development of Human Lung Induction Models for Air Pollutants’ Toxicity Assessment
Shuyu Liu, Renjun Yang, Yongjiu Chen, Xingchen Zhao, Shaokun Chen, Xuezhi Yang, Zhanwen Cheng, Bowen Hu, Xiaoxing Liang, Nuoya Yin, Qian Liu, Hailin Wang, Sijin Liu, Francesco Faiola
Abstract
. Thus, hLP and ATL induction models could facilitate the evaluation of environmental pollutants potentially affecting the lungs. In conclusion, this is one of the first studies that managed to adopt hPSC pulmonary induction models in toxicology studies.
Topics & Concepts
Induced pluripotent stem cellPollutantBenzo(a)pyreneProgenitor cellToxicityLungPulmonary toxicityCell biologyChemistryToxicologyBiologyStem cellMedicineCarcinogenEmbryonic stem cellBiochemistryInternal medicineOrganic chemistryGeneNeonatal Respiratory Health ResearchRenal and related cancers