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Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial

John H. Krystal, John M. Kane, Christoph U. Correll, David P. Walling, Matthew Leoni, Sridhar Duvvuri, Shrinal Patel, Ih Chang, Philip Iredale, Lillian Frohlich, Stacey Versavel, Pamela Perry, Raymond Sanchez, John J. Renger

2022The Lancet109 citationsDOI

Topics & Concepts

TolerabilityPlaceboMedicinePopulationExtrapyramidal symptomsSchizophrenia (object-oriented programming)Clinical endpointRandomized controlled trialAdverse effectInternal medicinePsychiatryAntipsychoticPathologyAlternative medicineEnvironmental healthReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors StudyVagus Nerve Stimulation Research
Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial | Litcius