Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial
John H. Krystal, John M. Kane, Christoph U. Correll, David P. Walling, Matthew Leoni, Sridhar Duvvuri, Shrinal Patel, Ih Chang, Philip Iredale, Lillian Frohlich, Stacey Versavel, Pamela Perry, Raymond Sanchez, John J. Renger
Topics & Concepts
TolerabilityPlaceboMedicinePopulationExtrapyramidal symptomsSchizophrenia (object-oriented programming)Clinical endpointRandomized controlled trialAdverse effectInternal medicinePsychiatryAntipsychoticPathologyAlternative medicineEnvironmental healthReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors StudyVagus Nerve Stimulation Research