Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development
Meng Yang, Qingli Liu, Tongling Huang, Wenjuan Tan, Linbing Qu, Tianke Chen, Haobo Pan, Ling Chen, Jinsong Liu, Chi‐Wai Wong, William W. Lu, Min Guan
Abstract
Our results highlight ERRα as a key mediator which contributes to the sex disparity in NAFLD development, suggesting that selectively restoring ERRα activity in the liver may be a novel strategy for treating NAFLD/NASH.
Topics & Concepts
EndocrinologyInternal medicineVery low-density lipoproteinSteatohepatitisEstrogenBiologyMicrosomal triglyceride transfer proteinFatty liverHepcidinEstrogen receptor alphaEstrogen receptorLipoproteinCholesterolMedicineDiseaseInflammationCancerBreast cancerLiver Disease Diagnosis and TreatmentLipid metabolism and biosynthesisCholesterol and Lipid Metabolism