Human Gray and White Matter Metabolomics to Differentiate APOE and Stage Dependent Changes in Alzheimer’s Disease
Tyler C. Hammond, Xin Xing, Lucy M Yanckello, Arnold J. Stromberg, Ya‐Hsuan Chang, Peter T. Nelson, Ai‐Ling Lin
Abstract
Alzheimer’s disease (AD) is the most common form of dementia with hallmarks of ?-amyloid (A?) plaques, tau tangles, and neurodegeneration. Studies have shown that neurodegeneration components, especially brain metabolic deficits, are more predictable for AD severity than A? and tau.
Topics & Concepts
NeurodegenerationWhite matterMetabolomicsBiologyCreatineCitric acid cycleAlzheimer's diseaseGrey matterPhosphocholineLipid metabolismInternal medicineEndocrinologyBiochemistryDiseasePhospholipidMetabolismMedicineBioinformaticsPhosphatidylcholineRadiologyMembraneMagnetic resonance imagingMetabolomics and Mass Spectrometry StudiesAlzheimer's disease research and treatmentsDiet and metabolism studies