Renin-angiotensin system-mediated nitric oxide signaling in podocytes
Marharyta Semenikhina, Ruslan Bohovyk, Mykhailo Fedoriuk, Mariia Stefanenko, Christine A. Klemens, Jim C. Oates, Alexander Staruschenko, Oleg Palygin
Abstract
The renin-angiotensin system plays a crucial role in the production of intracellular nitric oxide within podocytes. This mechanism operates through the activation of the angiotensin II type 2 receptor, leading to dynamic modifications in intracellular calcium levels and the actin filament network. This intricate process is vital for linking the activity of angiotensin receptors to podocyte function.
Topics & Concepts
PodocyteCell biologyAngiotensin IIIntracellularActin cytoskeletonCrosstalkRenin–angiotensin systemNitric oxideSignal transductionChemistryReceptorConfocal microscopyCytoskeletonBiologyInternal medicineEndocrinologyKidneyCellBiochemistryMedicineProteinuriaOpticsBlood pressurePhysicsRenal Diseases and GlomerulopathiesPregnancy and preeclampsia studiesRenin-Angiotensin System Studies