Direct C–H Carboxylation Forming Polyfunctionalized Aromatic Carboxylic Acids by Combined Brønsted Bases
Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa‐Kumada, Yoshinori Kondo
Abstract
CO2 fixation into electron-deficient aromatic C–H bonds proceeds with the combined Brønsted bases LiO-t-Bu and LiO-t-Am/CsF/18-crown-6 (t-Am = CEtMe2) under a CO2 atmosphere to afford a variety of polyfunctionalized aromatic carboxylic acids.
Topics & Concepts
ChemistryCarboxylationAromaticityBrønsted–Lowry acid–base theoryCarboxylic acidOrganic chemistryMedicinal chemistryCrown (dentistry)CatalysisMoleculeDentistryMedicineCarbon dioxide utilization in catalysisFluorine in Organic ChemistryCatalytic C–H Functionalization Methods