Isolable Pyridinium Trifluoromethoxide Salt for Nucleophilic Trifluoromethoxylation
Geraldo Duran-Camacho, Devin M. Ferguson, Jeff W. Kampf, Douglas C. Bland, Melanie S. Sanford
Abstract
An isolable pyridinium trifluoromethoxide salt is prepared from the reaction of 4-dimethylaminopyridine with the commercially available liquid 2,4-dinitro(trifluoromethoxy)benzene. The salt is an effective trifluoromethoxide source for SN2 reactions to form trifluoromethyl ethers.
Topics & Concepts
ChemistryPyridiniumSalt (chemistry)SN2 reactionNucleophileBenzeneTrifluoromethylOrganic chemistryMedicinal chemistryCatalysisAlkylFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsSynthesis and Biological Evaluation