Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism
Laurent Cléret de Langavant, Emmanuel Roze, Aimée Petit, B. Tressières, Amin Gharbi‐Meliani, Hugo Chaumont, Patrick P. Michel, Anne‐Catherine Bachoud‐Lévi, Philippe Rémy, Régine Edragas, Annie Lannuzel
Abstract
Abstract Background High consumption of Annona muricata fruit has been previously identified as a risk factor for atypical parkinsonism in the French Caribbean islands. Objective We tested whether consumption of Annonaceae products could worsen the clinical phenotype of patients with any form of degenerative parkinsonism. Methods We analyzed neurological data from 180 Caribbean parkinsonian patients and specifically looked for dose effects of lifelong, cumulative Annonaceae consumption on cognitive performance. Using unsupervised clustering, we identified one cluster with mild/moderate symptoms (N = 102) and one with severe symptoms including cognitive impairment (N = 78). Results We showed that even low cumulative consumption of fruits/juices (>0.2 fruit‐years) or any consumption of herbal tea from Annonaceae worsen disease severity and cognitive deficits in degenerative parkinsonism including Parkinson's disease (OR fruits‐juices: 3.76 [95% CI: 1.13–15.18]; OR herbal tea: 2.91 [95% CI: 1.34–6.56]). Conclusion We suggest that more restrictive public health preventive recommendations should be made regarding the consumption of Annonaceae products. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.