Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
Martin Trapečar, Emile Wogram, Devon S. Svoboda, Catherine Communal, Attya Omer, Tenzin Lungjangwa, Pierre Sphabmixay, Jason Velazquez, Kirsten Schneider, Charles Wright, Samuel Mildrum, Austin Hendricks, Stuart S. Levine, Julien Muffat, Meelim Jasmine Lee, Douglas A. Lauffenburger, David L. Trumper, Rudolf Jaenisch, Linda G. Griffith
Abstract
regulatory T and T helper 17 cells. We demonstrate this approach using a patient-derived cerebral MPS carrying the PD-causing A53T mutation, gaining two important findings: (i) that systemic interaction enhances features of in vivo-like behavior of cerebral MPSs, and (ii) that microbiome-associated short-chain fatty acids increase expression of pathology-associated pathways in PD.
Topics & Concepts
Context (archaeology)Induced pluripotent stem cellMicrobiomeImmune systemNeuroscienceGut microbiomeBiologyDiseaseImmunologyBioinformaticsMedicinePathologyGeneGeneticsPaleontologyEmbryonic stem cellGut microbiota and healthDiet and metabolism studiesPancreatic function and diabetes