Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment
Rehab Abdelmonem, Hadel A. Abo El-Enin, Ghada Abdel Kader, Mohamed Abdel-Hakeem
Abstract
) and dissolution rate (> 80% within 10 min) for rapid in vivo bio-distribution. In vivo studies showed considerable improvement brain and plasma's rate and extent absorption after intranasal administration indicating a high brain targeting efficiency. The results achieved indicate that nano-spanlastic nasal-inserts offer a promising LMT brain targeting in order to maximize its antiepileptic effect.
Topics & Concepts
Nasal administrationLamotrigineBioavailabilityPharmacokineticsPharmacologyMaterials scienceMucoadhesionIn vivoDrug deliverySolubilityZeta potentialChemistryDrug carrierNanotechnologyMedicineEpilepsyNanoparticleOrganic chemistryPsychiatryBiotechnologyBiologyAdvanced Drug Delivery SystemsDrug Transport and Resistance MechanismsRNA Interference and Gene Delivery