Chronic stress physically spares but functionally impairs innate-like invariant T cells
Patrick T. Rudak, Joshua Choi, Katie M. Parkins, Kelly L. Summers, Dwayne N. Jackson, Paula J. Foster, Anton Skaro, Ken Leslie, Vivian C. McAlister, Vijay K. Kuchroo, Wataru Inoue, Olivier Lantz, S. M. Mansour Haeryfar
Abstract
2-type responses. The above findings are corroborated in human peripheral blood and hepatic iNKT/MAIT cell cultures. Our work uncovers a mechanism of stress-induced immunosuppression.
Topics & Concepts
ImmunologyInnate immune systemGlucocorticoid receptorInnate lymphoid cellBiologyNatural killer T cellProgrammed cell deathImmune systemCell biologyApoptosisGlucocorticoidT cellBiochemistryImmune Cell Function and InteractionT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways