Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity
Ekaterina S. Shchegravina, E. V. Svirshchevskaya, Sébastien Combes, Diane Allegro, Pascale Barbier, Benoı̂t Gigant, Paloma F. Varela, Andrei Gavryushin, Daria A. Kobanova, Andrey E. Shchekotikhin, Alexey Yu. Fedorov
Topics & Concepts
ChemistryColchicineTubulinStereochemistryAntimitotic AgentToxicityIn vitroPyranAcute toxicityCytotoxicityMicrotubuleStructure–activity relationshipChemical synthesisCell cultureCytotoxic T cellPharmacologyBiochemistryOrganic chemistryGeneticsCell biologyInternal medicineBiologyMedicineResearch on Leishmaniasis StudiesCancer therapeutics and mechanismsGenomics, phytochemicals, and oxidative stress