Design and biological activity of a novel fungicide, quinofumelin
Hiroyuki Ito, Takeshi Takada, Munetsugu Morimoto, Hiroyuki Komai, Fumie Kajino, Toshiaki Ohara, Yasushi Tamagawa, Mikio Tsuda, Shinichi Banba
Abstract
Developed by Mitsui Chemicals Agro, Inc. (Tokyo, Japan), quinofumelin is a novel fungicide with a distinct chemical structure including 3-(isoquinolin-1-yl) quinoline, demonstrating fungicidal activity against a variety of fungi, including rice blast and gray mold. We screened our compound library to identify curative compounds for rice blast and evaluated the effect of fungicide-resistant strains of gray mold. Our research demonstrated that quinofumelin has curative effects against rice blast and is not cross-resistant to existing fungicides. Accordingly, the use of quinofumelin can be considered a novel approach for disease control in agricultural production. In this report, the discovery of quinofumelin from the initial compound is described in detail.