Milk-derived extracellular vesicles enable gut-to-tumor oral delivery of tumor-activated doxorubicin prodrugs
Hochung Jang, Jiwoong Choi, Daeho Park, Geonhee Han, Eun Hye Kim, Kwangmeyung Kim, Sun Hwa Kim, Man Kyu Shim, Yoosoo Yang
Abstract
After oral administration of FDX@mEVs, it is observed that remarkable antitumor efficacy in colon tumor-bearing mice without adverse effects, such as body weight loss, liver/kidney dysfunction, and cardiotoxicity.
Topics & Concepts
ProdrugExtracellular vesiclesDoxorubicinChemistryVesicleDrug deliveryExtracellularPharmacologyCancer researchMedicineBiochemistryCell biologyChemotherapyBiologyInternal medicineMembraneOrganic chemistryExtracellular vesicles in diseaseTissue Engineering and Regenerative Medicine