Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet
Dustin M. Lee, Kayl E. Ecton, S. Raj J. Trikha, Scott D. Wrigley, Keely N. Thomas, Micah L. Battson, Yuren Wei, Sarah A. Johnson, Tiffany L. Weir, Christopher L. Gentile
2020American Journal of Physiology-Gastrointestinal and Liver Physiology32 citationsDOIOpen Access PDF
Abstract
The gut microbiota has been shown to mediate host health. Emerging data implicate gut microbial metabolites of tryptophan metabolism as potential important mediators. We examined the effects of indole-3-propionic acid in Western diet-fed mice and found no beneficial cardiometabolic effects. Our data do not support the supposition that indole-3-propionic acid (IPA) mediates beneficial metabolic effects downstream of the gut microbiota and may be potentially deleterious in higher circulating levels.
Topics & Concepts
MetaboliteGut floraIndole testMetabolismTryptophanMicrobial metabolismBiologyBiochemistryChemistryBacteriaAmino acidGeneticsGut microbiota and healthDiet and metabolism studiesTryptophan and brain disorders