Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention
Chiara Lanzillotta, Ilaria Zuliani, Antonella Tramutola, Eugenio Barone, Carla Blarzino, Valentina Folgiero, Matteo Caforio, Diletta Valentini, Alberto Villani, Franco Locatelli, D. Allan Butterfield, Elizabeth Head, Marzia Perluigi, Jose F. Abisambra, Fabio Di Domenico
Topics & Concepts
ATF4Integrated stress responseUnfolded protein responseNeuroscienceNeuropathologyBiologyTranscription factorCell biologyProteostasisMedicineTranslation (biology)DiseaseInternal medicineGeneticsGeneMessenger RNAEndoplasmic reticulumEndoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseDown syndrome and intellectual disability research