Phenotyping of immune and endometrial epithelial cells in endometrial carcinomas revealed by single-cell RNA sequencing
Yue Guo, Yiran Li, Bailian Cai, Qizhi He, Guofang Chen, Mengfei Wang, Kai Wang, Xiaoping Wan, Qin Yan
Abstract
T cells and macrophages comport with continuous activation model. Gene expression patterns examination and gene ontology enrichment analysis of endometrial epithelial cells revealed 3 subtypes: stem-like cells, secretory glandular cells and ciliated cells. Overall, our study presents a view of endometrial carcinoma at single-cell resolution that reveals the characteristics of endometrial epithelial cells in the endometrium, and provides a cellular landscape of the tumor immune microenvironment.
Topics & Concepts
Endometrial cancerRNACancer researchImmune systemCellBiologyOncologyMedicineGeneImmunologyCancerGeneticsSingle-cell and spatial transcriptomicsCancer Cells and MetastasisImmune cells in cancer