Repressing MYC by targeting BET synergizes with selective inhibition of PI3Kα against B cell lymphoma
Ziqi Chen, Zhe-rui Cao, Yi Wang, Xi Zhang, Lan Xu, Yuxiang Wang, Yi Chen, Chunhao Yang, Jian Ding, Linghua Meng
Topics & Concepts
PI3K/AKT/mTOR pathwayCancer researchIdelalisibProtein kinase BBET inhibitorCell growthAcetylationBromodomainCell cycleBiologyApoptosisKinaseCell cycle checkpointChemistryCell biologyBiochemistryImmunologyChronic lymphocytic leukemiaLeukemiaGeneIbrutinibProtein Degradation and InhibitorsCAR-T cell therapy researchMultiple Myeloma Research and Treatments