SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages
Fan Yang, Zijie Gao, Jianye Xu, Huizhi Wang, Qindong Guo, Boyan Li, Ming O. Li, Hao Xu, Yanhua Qi, Shulin Zhao, Wei Qiu, Ziwen Pan, Qingtong Wang, Hao Xue, Rongrong Zhao, Xing Guo, Gang Li
Abstract
This study demonstrates that targeting SPI1 to block transcription of the MIR222HG cluster helps to reduce radioresistance and combat the immunosuppressive microenvironment in GBM. PLX-4720 is a potential GBM drug and radiosensitizer.
Topics & Concepts
RadioresistanceBiologyCancer researchGliomaTranscription factorStem cellmicroRNACell biologyGeneCell cultureGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA Research and Splicing