iMATCH: an integrated modular assembly system for therapeutic combination high-capacity adenovirus gene therapy
Dominik Brücher, Nicole Kirchhammer, Sheena N. Smith, Jatina Schumacher, Nina Schumacher, Jonas Kolibius, Patrick C. Freitag, Markus Schmid, Fabian Weiss, Corina Keller, Melanie Grove, Urs F. Greber, Alfred Zippelius, Andreas Plückthun
Abstract
. Therefore, the iMATCH system provides a versatile platform for the generation of high-capacity gene therapy vectors with a high potential for clinical development.
Topics & Concepts
Genetic enhancementComputational biologyGeneCapsidBiologyFusion proteinCancer researchRecombinant DNAGeneticsVirus-based gene therapy researchCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in Insects