The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity
Jizhang Yu, Jikai Cui, Xi Zhang, Heng Xu, Zhang Chen, Yuan Li, Yuqing Niu, Song Wang, Shuan Ran, Yanqiang Zou, Weicong Ye, Dan Zhang, Cheng Zhou, Jiahong Xia, Jie Wu
Topics & Concepts
Cytotoxic T cellCD8T cellCancer researchImmune checkpointCTLA-4ImmunityImmune systemBlockadeImmunotherapyCell biologyBiologyImmunologyChemistryReceptorIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionT-cell and B-cell Immunology