Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model
Philipp Spatz, Thomas Zimmermann, Sophie A. M. Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decker
Abstract
Benzimidazole-based inhibitors of butyrylcholinesterase were designed and tested for their activity and selectivity in vitro , leading to compound (11d) that attenuated Aβ 25-35 -induced learning impairments in an Alzheimer's disease mouse model.
Topics & Concepts
ButyrylcholinesteraseBenzimidazoleNeuroprotectionCholinesterasePharmacologyAlzheimer's diseaseNeuroscienceDiseaseChemistryMedicineBiochemistryAcetylcholinesteraseBiologyAchéEnzymeInternal medicineOrganic chemistryCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsNicotinic Acetylcholine Receptors Study