Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination
Irina Stefanelli, Angela Corona, Carmen Cerchia, E Cassese, Salvatore Improta, Elisa Costanzi, Sveva Pelliccia, Stefano Morasso, Francesca Esposito, Annalaura Paulis, Sante Scognamiglio, Francesco Saverio Di Leva, Paola Storici, Margherita Brindisi, Enzo Tramontano, Rolando Cannalire, Vincenzo Summa
Topics & Concepts
PeptidomimeticChemistryProteaseViral replicationCoronavirusVirologyStructure–activity relationshipActive siteRational designEnzymeStereochemistryBiochemistryVirusIn vitroCoronavirus disease 2019 (COVID-19)BiologyPeptideMedicineGeneticsPathologyInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsRNA and protein synthesis mechanisms