High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma
Lucie Lafay‐Cousin, Christelle Dufour
Abstract
High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribution to improved survival and describe their toxicity profile and limitations.
Topics & Concepts
MedulloblastomaMedicineChemotherapyRadiation therapyOncologyToxicitySalvage therapyAdjuvant chemotherapyAdjuvantInternal medicineCancerPathologyBreast cancerGlioma Diagnosis and TreatmentNeuroblastoma Research and TreatmentsOcular Oncology and Treatments