Assessing the Bioactive Profile of Antifungal-Loaded Calcium Sulfate against Fungal Biofilms
Mark C. Butcher, Jason L. Brown, Donald Hansom, Rebecca Wilson-van Os, Craig Delury, Phillip A. Laycock, Gordon Ramage
Abstract
Calcium sulfate (CS) has been used clinically as a bone- or void-filling biomaterial, and its resorptive properties have provided the prospect for its use as a release mechanism for local antibiotics to control biofilms. Here, we aimed to test CS beads loaded with three antifungal drugs against planktonic and sessile fungal species to assess whether these antifungal beads could be harnessed to provide consistent release of antifungals at biofilm-inhibitory doses.
Topics & Concepts
BiofilmAntifungalMicrobiologyCalciumAntibioticsChemistryCheckerboardPharmacologyBiologyBacteriaGeneticsOrganic chemistryBacterial biofilms and quorum sensingAntifungal resistance and susceptibilityDental materials and restorations