Total synthesis of atropisomeric indolosesquiterpenoids <i>via</i> N–N bond formation: dixiamycins A and B
Rhituparna Nandi, Sovan Niyogi, Sourav Kundu, Vipin R. Gavit, Mintu Munda, Ranjit Murmu, Alakesh Bisai
Abstract
The total synthesis of the naturally occurring N–N atropo-diastereomers dixiamycin A (1a) and dixiamycin B (1b) using a key Cu( i )-catalyzed aerobic oxidation of xiamycin A methyl ester (2b) was developed.
Topics & Concepts
MonomerChemistryTotal synthesisStereochemistryCombinatorial chemistryOrganic chemistryPolymerAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacologyMarine Sponges and Natural Products