Antiproliferative Activities of the Lipophilic Fraction of <i>Eucalyptus camaldulensis</i> against MCF-7 Breast Cancer Cells, UPLC-ESI-QTOF-MS Metabolite Profile, and Antioxidative Functions
Yanping Huang, Mei An, Anning Fang, Opeyemi Joshua Olatunji, Fredrick Nwude Eze
Abstract
> 80 μg/mL), suggestive of its selective anticancer properties. Spectrophotometric, UHPLC-MS, and GC-MS analysis revealed that Lipo-Eucam is rich in phenolics, flavonoids, terpenoids, volatile constituents, and a plethora of active metabolites, probably responsible for the observed activities. These findings indicate that Lipo-Eucam is endowed with pharmacologically relevant active principles with strong potential for use in the amelioration of disease conditions related to oxidative stress, protein aggregation, and breast cancer and therefore worthy of further investigations.
Topics & Concepts
ChemistryABTSEucalyptus camaldulensisDPPHSecondary metaboliteMetaboliteIC50ChromatographyDefattingAntioxidantOxidative stressBovine serum albuminBiochemistryIn vitroBiologyGeneEcologyEucalyptusPhytochemistry and Biological ActivitiesEssential Oils and Antimicrobial ActivityPhytochemicals and Antioxidant Activities