Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions
Juan D. Lasso, Durbis J. Castillo‐Pazos, Chao‐Jun Li
Abstract
)-H functionalizations, as well as the utilization of heteroatom-containing functional groups as chemical handles. Selected topics such as metal-free cross-dehydrogenative coupling (CDC) reactions, organocatalysis, electrochemistry and photochemistry are also discussed. By writing the first review on metal-free LSF methodologies, we aim to highlight current advances in the field with examples that reveal specific challenges and solutions, as well as future research opportunities.
Topics & Concepts
Surface modificationChemistryNanotechnologyCombinatorial chemistryMaterials sciencePhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms