Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer
Zhongpeng Ding, Feifei Li, Changjiang Zhong, Feng Li, Yuqian Liu, Shixiao Wang, Jianchun Zhao, Wenbao Li
Topics & Concepts
ChemistryMoietyStereochemistryFuranTubulinSubstituentMicrotubule polymerizationStructure–activity relationshipNatural productImidazoleMicrotubuleBiochemistryIn vitroOrganic chemistryBiologyCell biologyCancer therapeutics and mechanismsMicrobial Natural Products and BiosynthesisSynthesis and biological activity