Microbiome Engineering Using Probiotic Yeast: <i>Saccharomyces boulardii</i> and the Secreted Human Lysozyme Lead to Changes in the Gut Microbiome and Metabolome of Mice
Jungyeon Kim, Christine Atkinson, Michael J. Miller, Kyoung Heon Kim, Yong‐Su Jin
Abstract
Our study identified changes in the microbiome by administering wild-type S. boulardii in mice to healthy mice based on long-read sequencing and demonstrated that a recombinant protein secreted by engineered S. boulardii in the intestine could change the microbiome. Our results provide valuable information for the development of therapeutics using engineered S. boulardii that changes the gut microbiome and host physiology.
Topics & Concepts
Saccharomyces boulardiiMicrobiomeBiologyProbioticMicrobiologyYeastLysozymeGut floraImmunologyBacteriaBiochemistryBioinformaticsGeneticsGut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens research