Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer
Zhefang Wang, Jie Qin, Jiangang Zhao, Jiahui Li, Dai Li, Marie Popp, Felix Popp, Hakan Alakus, Bo Kong, Qiongzhu Dong, Peter J. Nelson, Yue Zhao, Christiane J. Bruns
Abstract
These results effectively demonstrate a central mechanism by which IFIT3 expression can affect chemotherapy resistance in PDAC. Targeting IFIT3/VDAC2 may represent a novel strategy to sensitize aggressive forms of pancreatic cancer to conventional chemotherapy regimens.
Topics & Concepts
ApoptosisCancer researchGene knockdownMedicineBiologyBiochemistryRNA modifications and cancerinterferon and immune responsesFerroptosis and cancer prognosis