Organic dust-induced mitochondrial dysfunction could be targeted via cGAS-STING or cytoplasmic NOX-2 inhibition using microglial cells and brain slice culture models
Nyzil Massey, Denusha Shrestha, Sanjana Mahadev Bhat, Naveen Kondru, Adhithiya Charli, Locke A. Karriker, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath
Topics & Concepts
Reactive oxygen speciesBiologyDNA damageMFN2Molecular biologyCell biologyMitochondrial DNABiochemistryDNAmitochondrial fusionGeneinterferon and immune responsesNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation