Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex
Yuchuan Li, Prabhat Khanal, Frode Norheim, Marit Hjorth, Thomas Bjellaas, Christian A. Drevon, Jarle Vaage, Alan R. Kimmel, Knut Tomas Dalen
Abstract
mice displayed unexpectedly high levels of phosphatidylglycerols, which directly paralleled the accumulation of these ceroid-like structures. Our findings demonstrate an important role of Plin2 for regulation of CE-rich LDs and cellular cholesterol balance in the adrenal cortex.
Topics & Concepts
Lipid dropletAdrenal cortexCholesterolEndocrinologyInternal medicineCholesteryl esterChemistryBiologyCorticosteroneCell biologyHormoneLipoproteinMedicineLipid metabolism and biosynthesisCholesterol and Lipid MetabolismPlant biochemistry and biosynthesis