Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor
Tian Niu, Kailin Li, Jiang Li, Zhesheng Zhou, Ju-Eun Hong, Xuankun Chen, Xiaowu Dong, Qiaojun He, Ji Cao, Bo Yang, Cheng‐Liang Zhu
Topics & Concepts
Synthetic lethalityChemistryDNA damagePoly ADP ribose polymeraseCyclin E1CyclinCancer researchDNA repairBiologyCell cycleBiochemistryGeneDNAPolymeraseProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis