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Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model

Ganesh Routholla, Sravani Pulya, Tarun Patel, Nilanjan Adhikari, Sk. Abdul Amin, Milan Paul, Srividya Bhagavatula, Swati Biswas, Tarun Jha, Balaram Ghosh

2021Bioorganic Chemistry28 citationsDOI

Topics & Concepts

HDAC3ChemistryBenzamideAcetylationHistone deacetylaseToxicityApoptosisDownregulation and upregulationCancer researchPharmacologySmall moleculeHistoneBiochemistryStereochemistryBiologyOrganic chemistryGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis
Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model | Litcius