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Time of flight mass spectrometry based in vitro and in vivo metabolite profiling of ribociclib and their toxicity prediction

Amit Kumar Sahu, Pinaki Sengupta

2020Journal of Chromatography B28 citationsDOI

Topics & Concepts

ChemistryIn vivoMetaboliteAmmonium formateHydroxylationPharmacologyS9 fractionFormic acidToxicityGlucuronidationChromatographyIn vitroBiochemistryMicrosomeEnzymeBiologyOrganic chemistryBiotechnologyAdvanced Breast Cancer TherapiesPARP inhibition in cancer therapyCancer therapeutics and mechanisms
Time of flight mass spectrometry based in vitro and in vivo metabolite profiling of ribociclib and their toxicity prediction | Litcius