A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome
Shenghui Li, Ruochun Guo, Yue Zhang, Peng Li, Fang Chen, Xifan Wang, Jing Li, Zhuye Jie, Qingbo Lv, Hao Jin, Guangyang Wang, Qiulong Yan
Abstract
phages and jumbo viruses. Comparisons of the viral diversity and abundance of different oral cavity habitats suggested strong niche specialization of viromes within individuals. The virome variations in relation to host geography and properties were further uncovered, especially the age-dependent viral compositional signatures in saliva. Overall, the viral genome catalog describes the architecture and variability of the human oral virome, while offering new resources and insights for current and future studies.
Topics & Concepts
Human viromeBiologyComputational biologyMetagenomicsGeneticsGeneBacteriophages and microbial interactionsRespiratory viral infections researchViral gastroenteritis research and epidemiology