Transition-metal-free mono- or dinitration of protected anilines
Enrui Dai, Yongrui Dong, Rui Kong, Guangzhang Liu, Ying Dong, Qiong Wu, Deqiang Liang, Yinhai Ma
Abstract
An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO<sub>2</sub> and NaNO<sub>3</sub> as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and <i>ortho</i>–<i>para</i> selectivity.
Topics & Concepts
ChinaChemistryCenter (category theory)Science and engineeringEngineering physicsLibrary scienceEngineeringArchaeologyEngineering ethicsGeographyCrystallographyComputer scienceAsymmetric Hydrogenation and CatalysisNanomaterials for catalytic reactionsCatalytic C–H Functionalization Methods