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An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα–CPT1A axis

Qiming Xiao, Xixi Yu, Xinwei Yu, Shundi Liu, Jianping Jiang, Yu Cheng, Hao Lin, Yuzhen Wang, Xiaoshan Zhang, Xiaoxia Ye, Zheng Xiang

2022Phytomedicine32 citationsDOI

Topics & Concepts

MetabolitePharmacologyBeta oxidationPeroxisome proliferator-activated receptorLipid metabolismMetabolomicsChemistryAgonistBiologyReceptorBiochemistryFatty acidBioinformaticsChronic Kidney Disease and DiabetesPeroxisome Proliferator-Activated ReceptorsLiver Disease Diagnosis and Treatment
An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα–CPT1A axis | Litcius