Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
Hui Zhang, Wenwen Dong, Siyuan Li, Yunqian Zhang, Lv Zhou, Lu Yang, Lai Jiang, Tao Wu, Yan Wang
Abstract
CONTEXT: L. (Crassulaceae), possesses many beneficial pathological effects. OBJECTIVE: . MATERIALS AND METHODS: , mouse lung vascular endothelial cells (MLVECs) were treated with salidroside, MMP-9 siRNA, and BAY11-7082 (10 μM), and then exposed to cyclic stretch for 4 h. Afterward, lung tissues and MLVECs were collected for further analysis. RESULTS: 0.81 ± 0.11) in stretched MLVECs. Meanwhile, salidroside inhibited the NF-κB signalling pathway and alleviated lung injury. CONCLUSIONS: Salidroside protected against stretch-induced endothelial barrier function, improving lung injury after ventilation. Thus, salidroside may be a promising therapeutic agent for patients with MV-induced lung injury.