Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation
Naga Rajiv Lakkaniga, Gunaganti Naresh, Lingtian Zhang, Binyam Belachew, Brendan Frett, Yuet‐Kin Leung, Hongyu Li
Topics & Concepts
ChemistryPyrimidineBioisostereLead compoundProto-Oncogene Proteins c-retCancer researchPyrimidine metabolismMutantCell cultureStructure–activity relationshipBiochemistryStereochemistryGeneIn vitroChemical synthesisEnzymeBiologyReceptorPurineGeneticsGlial cell line-derived neurotrophic factorNeurotrophic factorsLung Cancer Treatments and MutationsLung Cancer Research StudiesCancer-related Molecular Pathways