Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV
Upasana Das Adhikari, Leah Froehle, Alexandra N Pipkin, Heeva Baharlou, Alice H. Linder, Palak Shah, Amanda M. Hussey, Qiming Zhang, Sarah K. Nyquist, Saleh Khawaled, Fangtao Chi, Swagata Goswami, Sabhyata Sedhain, Salina Hussain, Thomas Diefenbach, Benjamin J. Read, Byungji Kim, Darrell J. Irvine, Osaretin E. Asowata, Mark S. Ladinsky, Pamela J. Björkman, Fusi Madela, Shakeel Kader, Alex K. Shalek, Musie Ghebremichael, Henrik N. Kløverpris, Alison E. Ringel, Ömer Yılmaz, Douglas S. Kwon
Topics & Concepts
BiologyIntracellularDownregulation and upregulationApoptosisImmunologyIntestinal epitheliumIntestinal mucosaCell biologyIntestinal DisorderLipid metabolismCancer researchTight junctionDiseaseCytotoxic T cellCaco-2EpitheliumAntiretroviral therapyPeroxisomeCell cultureHuman immunodeficiency virus (HIV)Lipid dropletEnterocyteCellImmune systemInflammatory bowel diseaseHIV Research and TreatmentHIV-related health complications and treatmentsImmune Cell Function and Interaction