Selective Fluorosulfonylation of Thianthrenium Salts Enabled by Electrochemistry
Xianqiang Kong, Yiyi Chen, Qianwen Liu, Wenjie Wang, Shuangquan Zhang, Qian Zhang, Xiaohui Chen, Yuanqing Xu, Zhong‐Yan Cao
Abstract
A practical electrochemically driven method for fluorosulfonylation of both aryl and alkyl thianthrenium salts has been disclosed. The strategy does not need external redox reagents or metal catalysts. In combination with C-H thianthrenation of aromatics, this method provides a new tool for the site-selective fluorosulfonylation of drugs.
Topics & Concepts
ChemistryElectrochemistryCombinatorial chemistryNanotechnologyElectrodePhysical chemistryMaterials scienceSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods