Switchable foldamer ion channels with antibacterial activity
Anna D. Peters, Stefan Borsley, Flavio della Sala, Dominic F. Cairns‐Gibson, Marios Leonidou, Jonathan Clayden, George F. S. Whitehead, Íñigo J. Vitórica‐Yrezábal, Eriko Takano, John Burthem, Scott L. Cockroft, Simon J. Webb
Abstract
Triazole-capped α-aminoisobutyric acid (Aib) octameric foldamers formed very active ion channels in phospholipid bilayers after the addition of copper(<sc>ii</sc>) chloride, with activity “turned off” by copper(<sc>ii</sc>) extraction.
Topics & Concepts
FoldamerIon channelAntibacterial activityChemistryCombinatorial chemistryIonStereochemistryBiologyBiochemistryBacteriaOrganic chemistryPaleontologyReceptorChemical Synthesis and AnalysisAntimicrobial Peptides and ActivitiesNicotinic Acetylcholine Receptors Study