Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform
Lakshmi Vasudevan, Marthe M. Vandeputte, Marie H. Deventer, Elise Wouters, Annelies Cannaert, Christophe P. Stove
Topics & Concepts
Functional selectivityμ-opioid receptorG protein-coupled receptorChemistryPharmacologyG proteinOpioidAgonistNOPHEK 293 cellsIntrinsic activityReceptorFentanylOpioid receptorBiologyBiochemistryReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPhosphodiesterase function and regulation