Physiological Characteristics of Germinated Oat (Avena sativa) Extract as Raw Material for Cosmetics
Ji U Hwang, Yung Yang, Tae Boo Choe
Abstract
Purpose: This study evaluated the antioxidant and anti-inflammatory ability of germinated and non-germinated oat (Avena sativa ) grain for developing a new cosmetic raw material. Methods: Some local oat grains were freeze-dried (cryodesiccated) and extracted using 95% ethanol to obtain a germinated oat, and the non-germinated oat extract was obtained by redrying. The oat grains were germinated at 20 for 5 days and extracted using the same procedure as described above. Subsequently, the extracts were applied to cultured cells to determine their antioxidant, anti-inflammatory, anti-melanogenic, and anti-aging effects. Results: For the extract of germinated oat, 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity, and nitric oxide (NO) generation inhibition ability was increased to 112% and 43%, respectively, compared with the non-germinated. The RAW264.7 cells stimulated with lipopolysaccharides (LPS) revealed that treatment with the germinated oat extract could downregulate the expression of inflammatory factors, such as cyclooxygenase 2, interleukin 1beta, and interleukin 6 by 35%, 17.5%, and 22%, respectively. This enhanced anti-inflammatory effect could be as a result of increased avenanthramide during the germination period. Conclusion: Germinated oat grain extract showed an enhanced ability of antioxidant and anti-inflammatory properties. For this reason, the extract of germinated oat grain can be a good source of raw material for cosmetic industry.