Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles
Liang Ding, Wenjing Zhou, Jian Zhang, Qingsong Tang, Weizhang Xiao, Ming Chen, Zhenya Shen, Weiqian Chen
Abstract
not only restrains chemotaxis of inflammatory Mo/Mps but also relieves septic symptoms in mice by limiting the mobilization of splenic inflammatory monocytes and calming the subsequent serum cytokine storm. The current study provides functional evidence for the successful therapeutic targeting of septic inflammatory Mos, mandating the clinical development of CCR2 inhibition in patients with infectious diseases.
Topics & Concepts
Extracellular vesiclesSeptic shockMacrophageGene silencingMonocyteExtracellularCCR2VesicleInflammationCell biologySepsisMicrovesiclesChemistryMedicineImmunologyBiologyMembraneIn vitroChemokineBiochemistrymicroRNAGeneChemokine receptorExtracellular vesicles in diseaseImmune cells in cancerCell Adhesion Molecules Research